I've become completely addicted to This Week in Google (Twig) on Twit.tv. The show is hosted by Leo Laporte and usually features regulars Gina Trapani and Jeff Jarvis. Recommended! I actually learn new things from this show every week.
You can listen to the podcast and/or download the MP3 and even burn it to CDs like I do, to play in my car.
The show is recorded on Saturday evening at 17:15 ET, roughly, so you can watch the live video stream on the web page.